Protein Details: Glutamate [NMDA] receptor subunit 1

Protein ID

ICDB_Pro_0889

Protein Name

Glutamate [NMDA] receptor subunit 1

Gene Name

Nmdar1; GA15505

Organism

Drosophila pseudoobscura pseudoobscura (Fruit fly)

Length

1004 amino acids

AlphaFoldDB

AF-Q296F7-F1-model_v4.pdb

Function

NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. This protein plays a key role in synaptic plasticity

Sequence

MAGTDSPAAARFVYRCLLFAPAIVVGLLLPLTLPPIAAAQRHTASDNPSTYNIGGVLSNSESETYFHTIISHLNFDQQYVPRKVTYYDKTIRMDKNPIKTVFNVCDKLIENRVYAVVVSHEQTSGDLSPAAVSYTSGFYSIPVIGISSRDAAFSDKNIHVSFLRTVPPYYHQADVWLEMLSHFAYTKVIIIHSSDTDGRAILGRFQTTSQTYYDDVDVRATVELIVEFEPKLESFTEHLIDMKTAQSRVYLMYASTEDAQVIFRDAGEYNMTGEGHVWIVTEQALFANNTPDGVLGLQLEHAHSDKGHIRDSVYVLASAIKEMISNETIAEAPKDCGDSAVNWESGKRLFQYLKSRNITGETGQVAFDDNGDRIYAGYDVINIREHQKKHVVGKFSYDSMRAKMRMNINDSEIIWPGKQNRKPEGIMIPTHLKVLTIEEKPFVYVRRMGDDEFRCEPDERPCPLFNATDSTANEYCCRGYCIDLLIELSKRINFTYDLALSPDGQFGHYLLRNNTGAMTLRKEWTGLMGELVNERADMIVAPLTINPERAEYIEFSKPFKYQGITILEKKPSRSSTLVSFLQPFSNTLWILVMVSVHVVALVLYLLDRFSPFGRFKLSHSDSNEEKALNLSSAVWFAWGVLLNSGIGEGTPRSFSARVLGMVWAGFAMIIVASYTANLAAFLVLERPKTKLSGINDARLRNTMENLTCATVKGSSVDMYFRRQVELSNMYRTMEANNYATAEQAIQDVKKGKLMAFIWDSSRLEYEASKDCELVTAGELFGRSGYGVGLQKGSPWTDSVTLAILEFHESGFMEKLDKQWIFHGHVQQNCELFEKTPNTLGLKNMAGVFILVGVGIAGGVGLIIIEVIYKKHQVKKQKRLDIARHAADKWRGTIEKRKTIRASLAMQRQYNVGLNSTHPPGTISLAVDKRRYPRLGQRLGPERAWPGDAADVLRTRRPYELGKPGQSPKVMVATPAMLGRTRPQQNILPPRYSPGYTSDVSHLVV

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

542..544;549;715;759

Disease

Location

DOI ID

10.1101/gr.3059305

RefSeq

XP_001359355.1